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Ca 2 enters mitochondria via the mitochondrial calcium uniporter in the IMM, activating dehydrogenases in the tricarboxylic acid cycle and enhancing OXPHOS and ATP production, ensuring energy supply matches demand in cardiomyocytes and regulating synaptic transmission and plasticity in neurons

Autophagosomes also join the lysosomes to recycle their cargoes (Figure 1)

Oral supplements sit in a near-unregulated zone where manufacturers self-certify compliance and the FDA reacts only when something goes wronga contamination event, a serious adverse reaction, or a company making disease claims so egregious they can't be ignored

A point of interest however, is that the common mutations in the MMR genes that were identified in all four individuals tested, are likely to be LS predisposing gene mutations