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Free radicals or reactive species are indirectly associated with joint damage, as they play the role of secondary messenger in the immune and inflammatory response in RA

Results of a Randomized Phase III Study

An improvement in clinical symptoms was seen in a significantly higher percentage of patients in the treatment group, who inhaled a mixture of H 2 and O 2 , than in patients in the control group, who received classic oxygen therapy, although randomization was not applied because of the urgency to deal with the outbreak (Guan et al., 2 improves O 2 utilization rate, reduces O 2 consumption, and improves exercise endurance as in healthy humans (Alharbi et al., 2 and H 2 can expand the bronchioles and reduce the inspiratory effort, and thus promote the absorption of O 2 by the alveoli (Zhou et al., 2019)

Whether the early response after incision is mechanical sensitization remains controversial