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For example, most studies report that NCs are present in skeletally mature non-chondrodystrophic dogs, pigs, ferrets, rabbits, rats, and mice [4, 5, 8, 41], whereas in chondrodystrophic dogs, goats, horses, cows, and sheep, they disappear before skeletal maturity is reached [4, 5, 8, 80]

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*Correspondence: Luca Cucullo, [email protected] This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Timeframe Weeks 6-12 Commonly tracked Extended-cycle community reports Notes No human RCT covers this duration