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This is very close to the p53 tumor suppressor gene as well as to the chromosomal localization of a number of hereditary cancers unrelated to mutations in the p53 gene product PEDF thus becomes a prime candidate gene for these cancers

Nevertheless, if its senolytic action has been demonstrated in several diseases such as osteoarthritis 15,16 as well as in neurodegenerative diseases 17 , the effect of ABT-263 is restricted to senescent cells from specific cell types 18 , leading to the necessity to identify new potential senolytics to target senescent cells in age-related diseases

Its half-life is short (7 minutes) because it is rapidly cleaved by dipeptidyl peptidase-IV (DPP-IV) after residues 2-3