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wherein the compound has at least two non-hydrogen substituents at positions R 2 -R 8

Unlike earlier GH secretagogues, ipamorelin exhibits high selectivity, minimal activity at other hormonal axes (ACTH, cortisol, or prolactin), and potent GH release in both animals and humans

For people with type 2 diabetes, the SURPASS trial series demonstrated exceptional glycemic control alongside weight loss, which is why the compound received its first approval for diabetes before the obesity indication followed

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