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Thiamine is crucial for energy metabolism, and its deficiency can cause severe neurological and cardiac disorders

Duration of use: The drug is intended for prolonged use

The toxicity models described earlier are also based on acute toxicity and a narcotic mode of action, although (as this chapter highlights) there are many other mechanisms of action and sublethal effects that have implications at the individual, population, and ecosystem levels as a result of both acute (not lethal and also including delayed responses) and chronic longer-term exposures

However, repetitive strain, sudden trauma, or structural imbalances can cause these sacs to become inflamed, swollen, and irritated