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This again is a major oversimplification, as the theory (and the use of HRV as a general proxy) assumes namely that consistent patterns in the activity of different vegetative efferents (towards the heart, lung, gut etc) should be observed, but this prediction is frequently not verified (319)

This severe metabolic blockade reduces the transmitter content of individual vesicles by more than 50%, resulting in a dramatic decrease in quantal size and a rapid, dose-independent decay of the sympathomimetic response (Sulzer et al, 1995

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10.1038/s41467-019-10991-7 69 YuJ