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Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome

Research has demonstrated that the augmentation of NCOA4-mediated autophagic degradation of ferritin, commonly referred to as ferroautophagy, induces the accumulation of labile iron pool (LIP) and reactive oxygen species (ROS), ultimately leading to the occurrence of cell ferroptosis ( Research has substantiated that the expression of CACNA1G-AS1 is considerably elevated in ovarian cancer tissues and induces upregulation of FTH1 via IGF2BP1-mediated m6A methylation

J Am Soc Nephrol 25:978989

Perfluorooctanoic acid (PFOA) has a damaging effect on the liver, and vitamin C supplementation can reduce PFOA-induced total cholesterol and triglyceride levels and reduce abnormal enlargement of the liver, mainly by inhibiting linoleic acid metabolism and increasing glutathione in the liver (128)