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Furthermore, thiazolidinedione derivatives (e.g., rosiglitazone and pioglitazone) demonstrate selective inhibition of ACSL4, consequently attenuating ferroptosis progression (Sheng et al., 2024)

The increased NO bioavailability and the down-stream p53-mediated induction of PGC-1 favors the expression of NFE2L2 and its antioxidant-related genes ( Figure 1 )