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256 Animal studies show that mAbs targeting individual Notch ligands or receptors exert reduced intestinal toxicity, compared with that found by GSI treatment

But inadequate protein intake during rapid weight loss leads to muscle loss, metabolic rate reduction, and worse long-term outcomes

Consistent with this, focal application of SST to GFP-tagged GHRH neuron somata triggered a transient hyperpolarizing response, which inhibited action potential firing in both male and female hypothalamic slice preparations (Fig