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Extruded neuron-derived exopher vesicles enter the surrounding glial-like hypodermal cell via specialized phagocytosis so that exopher contents are then degraded by the hypodermal cells lysosomal network 9 , neuroprotective 6 transfer biology that may be conserved in flies 10,11 and mammalian neurons 12

For example, Tuveson et al have generated a genetically engineered mouse model of human pancreatic cancer that has dense stromal tissue, poor vascular perfusion, high interstitial fluid pressure, and resistance to chemotherapy, similar to human pancreatic cancer (Olive et al, 2009)

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Depression is categorized as a severe medical illness for personal and general mental health, and depression can be seen regardless of age, gender, and financial status [11,12,13]