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Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage

Comparing tirzepatide with B12 to other GLP-1 formulations Tirzepatide with B12 differs from semaglutide with B12 primarily through the dual GIP/GLP-1 mechanism

The systemic distribution of TB-500 means that a single injection can influence repair processes across multiple tissue sites simultaneously

These interactions may not only affect how well the body absorbs B12 but also how it metabolises and utilises the vitamin, potentially leading to an increase in discomfort post-injection