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Already in 1971 [i.e., 13 years after the first crystal structure of a protein, myoglobin, was solved in 1958 (Kendrew et al., 1958), and when only seven protein crystal structures were known (Minor et al., 2016)], a study on the X-ray crystal structure of staphylococcus nuclease first used the term disordered to describe two regions of missing electron density ( More recent analyses confirmed the prevalence of regions with missing electron density in protein structures deposited in the PDB (Le Gall et al., 2007

The inventors have also discovered that NNMT inhibitors may be used to inhibit NNMT and to treat related diseases or conditions