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This includes structural alterations in glutamatergic neurons, as well as changes in mRNA and protein expression of molecules involved in glutamate signaling (glutamate receptors, glutamate transporters, glutamate synthesizing enzymes, glutamate receptor co-agonists), although some inconsistencies have also been reported [30]

PAM, Peptidylglycine Alpha Amidating Monooxygenase

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The strategy delivers a functional CBS gene to the liver, via viral or non-viral vectors, to achieve sustained metabolic correction