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Many treatment modalities have been developed to restore the immune tolerance and immmunoregulatory balance in autoimmune rheumatic diseases, including the use of peptide-based therapeutics or the use of nanoparticles-based nanotechnology

The carrier ligand interacts with the SOD Receptor by forming two hydrogen bonds at the binding site

Interestingly, incubation of human skeletal muscle cells with serum obtained from these subjects after the intervention resulted in an increase in PGC-1 expression, AMPK and SIRT1 activity, and mitochondrial biogenesis