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However, the native one from pea is a homotetramer with a molecular weight of 156 kDa (the subunit molecular weight is 40 kDa), whereas the recombinant one from thale cress has monomeric and homodimeric conformations with molecular weights of 42.4 and 87.5 kDa, respectively (Gatzek et al., 2002)

This makes them important targets in cancer therapy and gives them significant potential in inducing senescence [81]

Although oxidative stress, ultraviolet radiation and metabolic dysfunction are welldocumented etiological factors, growing evidence implicates epigenetic dysregulation as a critical pathogenic mechanism in ARCs

doi: 10.1016/j.fbio.2013.07.001 19