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Under oxidative stress, Keap1 is modified and releases Nrf2 to enter the nucleus and promote gene transcription

Additionally, functionalized LNPs incorporating peptides that target receptors overexpressed on brain ECs and neuronssuch as RVG29, T7, AP2, and mApoEhave been demonstrated to enhance mRNA transfection in the mouse brain, while reducing hepatic accumulation following systemic administration [164]

Patients with COPD have high levels of TEM and during this process, the MAC-1, an important human cell surface receptor found on B and T lymphocytes, is upregulated [47]

This age-related incomplete vesicular mobilization could be targeted for pharmacological interventions to promote autophagic and endosomal pathways [49]