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Animal data and clinical studies indicate that prolonged use may lead to biosafety concerns such as hematological toxicity and depletion of essential trace elements [176, 178]

Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity

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Additionally, we explore the beneficial and damaging consequences of reactive astrogliosis in dopaminergic neurons during PD, particularly on oxidative damage, which is a main component of numerous neuropathological conditions, and that may have a damaging effect in astrocytic functions