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4.2.2 Polymeric nanoparticles 4.2.2.1 Poly(lactic-co-glycolic acid)-based nanoparticles Poly(lactic acid) (PLA) is widely used as an important biomaterial in DDS due to their excellent biocompatibility with the human body and undergoes degradation and clearance processes in which their by-products are non-toxic (Kumar and Kumar, 2019)

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Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose

More serious side effects like bone density changes and adrenal gland problems are rare and mostly tend to occur when people get too many cortisone shots