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Popescu, Anghelescu, Daia and Onose, 2015)

Intracellular IGF-1 is mainly expressed as proIGF-1Ea, not mature IGF-1 Using RT-PCR analyses, we previously demonstrated that skeletal muscles, adipose tissues and liver of several mammalian species mainly expressed the IGF-1Ea isoform, which represents about 90% of IGF-1 transcripts 5

For example, agents and compositions targeting IL-4, IL-4R , IL-13, and CD40 can be used to modulate monocyte and/or macrophage differentiation and/or polarization