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At the same time, ellagic acid also prevented the decrease of the mitochondrial membrane potential ( Yet another phenolic acid, rosmarinic acid, has been found to reduce the amount of reactive oxygen species and malondialdehyde, which in turn attenuates cellular oxidative stress and protects hydrogen peroxide-treated glial cells (Firdaus et al., 2018) by phosphorylating protein kinase B (Akt), Ser9 Glycogen synthase kinase-3 (GSK-3), and Fyn

The first step (for all OA patients) is following an anti-inflammatory diet (mainly the MD, rich in -3 PUFAs, fruits, vegetables, and whole grains), combined with weight loss of 510% (for those with a BMI 25) and low-impact exercises (such as swimming) for 3 months

Ultimately there is no one size fits all approach

doi: 10.1002/ijc.25592 177 RothschildD.WeissbrodO.BarkanE.KurilshikovA.KoremT.ZeeviD.et al