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In several preclinical studies, melatonin has proven itself worthy in the protection of neurons against iron-induced toxicity [396,397,398,399]

AUA categorizes body of evidence strength as Grade A (well-conducted RCTs or exceptionally strong observational studies), Grade B (RCTs with some weaknesses of procedure or generalizability or generally strong observational studies), or Grade C (observational studies that are inconsistent, have small sample sizes, or have other problems that potentially confound interpretation of data)

Hydroxocobalamin is a synthetic form of vitamin B12 that is utilized to manage both vitamin B12 deficiency and acute cyanide toxicity

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