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Renal Impairment Creatinine clearance was measured annually prior to dosing and changes in long-term renal function over 24 months were comparable in the Reclast and active control groups [see Warnings and Precautions (5.3)]

Frequency Depends on What You Need How often you get injections isn't one-size-fits-all

Although some of the nerve gaps become repaired through the natural mechanisms of the peripheral nervous system (PNS), extensive damages need to be reconstructed surgically [1]

So, artificially prolonging half-life through the use of a sustained-release formulation is another strategy to reduce drug adverse effects