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Administration of MPTP or rotenone in mice promotes the development of mitochondrial dysfunction via inhibition of mitochondrial complex I, suggesting that inhibition of mitochondrial complex I and propagation of mitochondrial dysfunction could be the primary event in PD neuropathology

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[DOI] [PubMed] [Google Scholar] 54.Gutop E.O., Linkova N.S., Kozhevnikova E.O., Fridman N.V., Ivko O.M., Khavinson V.K