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LRRK2 gene trigger lysosomal dysfunction and abnormal cellular response to membrane damage, leading to vesicular transport dysfunction, neuroinflammation, accumulation of alpha-synuclein, mitochondrial dysfunction and ciliary loss, ultimately leading to PD (Gustavsson et al., 2024

Disclosures: Christopher Sollenberger: Amphix Bio: Employee, Huai-En Chang: Nothing to Disclose, Mohammed Rifat Shaik: Nothing to Disclose, Hanna Blaney: Nothing to Disclose, Nancy Terry: Nothing to Disclose, Nancy Diazgranados: Nothing to Disclose, Christine Hsu: Nothing to Disclose 1482 HEPATIC STELLATE CELLS AND ALCOHOL: INVESTIGATING CANONICAL WNT/SS-CATENIN SIGNALING IN MODELS OF ALCOHOL-ASSOCIATED LIVER DISEASE Lauren Rutt 1 Rebecca McCullough 2 , 1 University of Colorado, Anschutz Medical Campus, 2 University of Colorado, Anschutz Medical Background: Alcohol- associated Liver Disease (ALD) is a leading cause of liver-related mortality and involves nearly 61 percent of the American population

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Blood sampling and storage were similar to those used for the captive khulans