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10.3390/cells11152262 131 GongL.HuangD.ShiY.LiangZ.BuH

Indeed, overexpression of wild-type IRP2 significantly increased tumor burden in a mouse xenograft model, but when a mutant version IRP2 lacking the 73 amino acid insert was overexpressed in the same model, this response was blunted ( IRP2 has also been implicated in tumor progression via its capacity to suppress translation of the tumor suppressor gene, tumor protein p53 (TP53) (Zhang et al., 2017)

Protein expression from high-copy number plasmids and powerful promoters will greatly exceed that of any native host protein, using up valuable resources in the cell thus leading to slowed growth

Do not use levocarnitine to treat serious carnitine deficiency unless prescribed by your doctor