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Key interventions include: Dietary changes : Mediterranean-style diet rich in vegetables, whole grains, lean proteins, and healthy fats Regular physical activity : At least 150 minutes of moderate-intensity exercise weekly Alcohol intake : For NAFLD, adhere to UK Chief Medical Officers' low-risk drinking guidelines (no more than 14 units per week, spread over three or more days)

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The Biological Basis for MOTS-c and 5-Amino-1MQ Synergy MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA that functions as a metabolic regulator by activating AMPK (AMP-activated protein kinase)the enzyme that shifts cellular metabolism from anabolic (energy storage) to catabolic (energy utilisation)

These findings bring closer their usage in human clinical trials