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GPX4 can be also modified post-transcriptionally by different processes such as ubiquitination of several lysine residues including Lys 47, 80, 107, 135, 162, 167 and 191, phosphorylation of Ser13, 40 and Tyr96, but also succinylation at Cys93 or alkylation at Cys107

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Under physiological conditions, PTCs can readily metabolize fatty acids, glutamine, and lactate to generate ATP via oxidative phosphorylation (OXPHOS), while other parts of the kidney such as glomeruli oxidize glucose by aerobic glycolysis and inner medulla by anaerobic glycolysis 15

Homocysteine is a toxic amino acid and, in the blood, homocysteine causes arterial sclerosis, putting strain on the heart and vascular system