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Flux along this pathway is likely to be increased under general conditions in which the mitochondrial NADH:NAD + ratio increases, which would include hypoxia and where there are deficiencies in NADH oxidation due to mitochondrial dysfunction

M.KelleherJ.WoodD

In experimental systems, the combination is studied as a model for examining how complementary peptide signaling pathways influence tissue remodeling and cellular repair responses