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Description

Vitamin E acts as a regulator of cellular metabolism, and its deficiency leads to anaemia, dysregulation of energy metabolism, irregular mitochondrial function, and tissue damage resulting from increased lipid peroxidation (170)

PDK1-deficient erythrocytes exhibit a reduced cytosolic Ca 2+ concentration and eryptosis upon exposure to cellular stressors [153]

As early as several decades ago, researchers recognized that cancer cells are more sensitive to elevated ROS levels compared to normal cells (185, 186)