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Pernicious anemia results from the destruction of the gastric parietal cells, with subsequent loss of intrinsic factor which leads to an inability to absorb vitamin B 12

10.1016/j.cbi.2014.10.016 76 LushchakV

Collectively, NAD + exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD + levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions 1-4