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Disrupting the Warburg effect re-routes cancer cells to OXPHOS offering a vulnerability point via ferroptosis-induced cell death

Its binding to VMAT2 is very strong, making it's effect appear irreversible, with trace amounts of the drug remaining bound to vesicular membranes for many days, and its clinical effects lasting many days to weeks, and may persist until new transporter proteins are synthesized (German et al, 2015

PNP, Purine nucleoside phosphorylase

The selection of patients who meet the TIMI (thrombolysis in myocardial infarction) electrocardiographic criteria for thrombolytic therapy is hampered by the high rate of abnormal or nondiagnostic ECGs in patients presenting with cocaine-associated chest pain