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Perioperative supplementation of EPA reduces immunosuppression induced by postoperative chemoradiation therapy in patients with esophageal cancer

The expression level of pyruvate dehydrogenase (encoding by aceE ), which catalyzes the reaction from pyruvate to the formation of acetyl-CoA, was only 0.13-fold in MG12345

This results in improvement of ROS clearance, enhancing the fusion process between functional organelles and the removal of dysfunctional mitochondria reduce thus reducing the onset of senescence (115)