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The COPI system: molecular mechanisms and function

Fernandez-Vazquez J, Vargas-Perez I, Sanso M, Buhne K, Carmona M, Paulo E, Hermand D, Rodriguez-Gabriel M, Ayte J, Leidel S, et al

The IMS plays a key role in numerous cellular functions, including protein and lipid biosynthesis, metal ion homeostasis, redox regulation, oxidative protein folding, initiation of apoptosis, and the maintenance of mitochondrial dynamics and structural integrity

This effect is also blocked by inhibitors of epidermal growth factor receptor (EGFR) and PI3K inhibitors, suggesting that the EGFR-PI3K pathway modulates PM 2.5 -induced MUC5AC expression ( Coordinated ciliary motion is important for the clearance of inhaled particles and irritants trapped in the mucus from the airways ( 2.5 exposure significantly aggravated ciliary deterioration and increased goblet cell hyperplasia in rabbits with chronic rhinosinusitis ( Figure 1 )