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Given these limitations, the development of novel asthma therapies with enhanced efficacy and fewer side effects requires a deeper understanding of the pathophysiological mechanisms underlying the development of the disease

An earlier short-term study by Murphy and colleagues examined a catabolic model: healthy volunteers were placed on caloric restriction, and MK-677 25 mg reversed diet-induced negative nitrogen balance over one week compared with placebo, suggesting a short-term nitrogen-retaining (anabolic) effect under catabolic stress

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