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Symptoms of endocarditis include: Chest pain while breathing Shortness of breath Dry or persistent cough A new or changed heart murmur (the sound made by the blood moving through your heart) Flu-like symptoms, such as chills and fever Aching joints and muscles Weakness or fatigue Night sweats Swelling in the feet, legs, or abdomen Unexplainable weight loss Blood in urine Tenderness in the spleen Red spots on the palms of the hands or soles of the feet (Janeway lesions) Red, tender spots under the skin of the fingers or toes (Oslers nodes) Tiny red or purple spots on the skin, inside the mouth, or in the whites of the eyes (petechiae) Heart Valve Disease Heart valve disease refers to the improper functioning of one or more of the four valves within the heart that open and close to control blood flow, meaning it disrupts blood flow through your heart to the rest of your body

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In both cases, the cytotoxic efficacy of TXNRD1 inhibition remained unaffected (H69 CPR , H526 CPR ) or only marginally decreased (H209 CPR ), while significant resistance to cisplatin was observed (Figs

Heme breakdown by HO-1 releases free iron, directly fueling iron-dependent peroxidation (140, 141)