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It has been reported that in studies where high doses of milk thistle were taken for long periods of time, only 1% of people experienced any side effects, meaning that for the most part, milk thistle is relatively risk-free, as stated in the American Family Physician scientific journal: Aside from mild gastrointestinal distress and allergic reactions, side effects are rare, and serious toxicity rarely has been reported

doi: 10.1002/glia.23872 9 AndersenJ

They may retain some pharmacological activity and can sometimes be more toxic than the parent compound