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The treatment of tap water creates disinfection byproducts that can affect the levels of minerals like calcium and magnesium in the water

Renal inflammation reduces the expression of SLC7A11, a cysteine transporter, and impairs the glutathione synthesis pathway, resulting in low expression of glutathione peroxidase 4 (a ferroptosis inhibitor)

Among them, GPX1-4 and 6 are selenocysteine-containing proteins

Niero EL, Rocha-Sales B, and Lauand C, et al (2014) The multiple facets of drug resistance: one history, different approaches J Exp Clin Cancer Res 33 37 PMID: 24775603 PMCID: 4041145 26