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These samples were left following preparation at room temperature, and were analysed by HPLC at time 0, 130 (2.2 h) and 260 min (4.3 h)

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APP-018, an analog of 4F which can be administered orally, reduced aortic root lesion in apo E-deficient mice (Navab et al., 2002)

Oxysterol inhibits cholesterol synthesis by directly silencing the expression of two enzymes, CYP51A1 and squalene synthase, via the nuclear hormone receptor for oxysterols, the liver X receptor (LXR) [77, 78]