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Description

Constitutive activation of -catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system

IGF-1 SIGNALING IN THE MODULATION OF ANABOLIC RESPONSES IN BONE In this section, we shall highlight two mechanisms by which IGF-1 exerts its action on the skeleton, specifically, by modulating the anabolic effects of parathyroid hormone (PTH) and through crosstalk with mechanosensing pathways