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10.1093/advances/nmac032 87

If it weakens, relaxes at the wrong times, or doesnt stay closed, stomach acid can move up into the esophagus

PT2385 is one of the very few HIF-2 inhibitors investigated in preclinical models of GBM and works by preventing allosteric heterodimerization with HIF-1 when it binds to HIF-2 PAS-B domain (156)