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Mechanistically, lactate accumulation, driven by PKM2, enhances Twist1-K150la, which in turn facilitates Twist1 phosphorylation, nuclear translocation, and regulation of TGFB1 transcription, thereby inducing an EndoMT-associated fibrotic phenotype in ischemic flaps

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Indeed, acetaminophen is safe when used as directed, but long-term daily use- particularly at or near the maximum recommended dose of 4,000 mg marks up the hazard of liver damage