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If you are considering B12 injections, here is an honest account of the risks of poor technique and how a clinic avoids them

While the reaction of the therapeutic antibody seems relatively straightforward on the myeloma side (as MM cells are FcR-negative), more complex interactions occur with effector cells (FcR + ), where the antibody can engage both the Fab-binding site and one of the FcRs on the same cell ( Figure 3 ) (110)

Then methyl B12 may help modulate your melatonin secretion, enhance your light sensitivity, and normalize your circadian and sleep-wake rhythm

So, the B12 in the serum is OK, but in the brain, it is low