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Reduced cobalamin availability leads to: Impaired enterocyte regeneration Villous atrophy and barrier dysfunction Increased intestinal permeability Secondary dysbiosis and chronic inflammation Clinically, this manifests as: Persistent anorexia Weight loss Chronic diarrhea Poor response to standard GI or pancreatitis therapy Low vitamin B12 concentrations have also been associated with increased disease severity and poorer prognosis in dogs with chronic enteropathy and inflammatory bowel disease

Even though there is no established evidence that BPC-157 requires tapering, its still a good idea to check in with the healthcare professional overseeing your treatment before making changes

Collagenase injections (Xiaflex) represent the most effective FDA-approved non-surgical treatment, with clinical studies showing 34% improvement in penile curvature

Another indirect link between B12 and the kidney is seen in Hemodialysis- a form of treatment used for kidney failure