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Ewha Med J

As a pharmacologic therapeutic, optimizing the efficacy of GSH and minimizing its unintended effects means it is crucial to determine the correct timing, dose, and disease context (Hong et al., 2005)

Taken together, these findings demonstrate that oral butyrate suppresses the mTORC1ISR axis both peripherally and centrally, thereby attenuating PBAT-MPs-induced microglial lipotoxicity, neuroinflammation, and cognitive decline via the gutbrain axis

Interestingly, genetic mouse models of heart-specific CPT I deletion exhibit significant left ventricular systolic dysfunction in response to pressure overload that exacerbates progressively with duration of CPT I gene knockout (He et al., 2012