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The authors inferred that smoking had a negative effect on radiological manifestations and delayed the time to sputum conversion, probably related to an attenuated IFN- response caused by direct tobacco smoke ( A prospective cohort study has been performed in India to determine the impact of smoking on TB treatment outcome and the prevalence of smoking habits among newly diagnosed individuals

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While highly debatable, this theory holds that impaired glucose metabolism in various parts of the brain may be a major contributing factor to the presence or severity of this disorder