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The above results suggest that 1D228 may exert anti-tumor effects as a dual target drug of c-Met and TRK, and may have clinical benefit populations

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ERK1/2 activation triggers transcription factors c-Fos and c-Jun that coordinate cellular repair responses

Due to inconsistent units of measurement across studies, the standardized mean difference (SMD) was adopted as the common effect size metric, with Hedges g used for small-sample correction (Lifeng Lin and Aloe, 2021)