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Notably, a statistically significant reduction in CCL2 mRNA was exclusively observed in the control group (from 2 0.2 to 2 0.1 , p = 0.01), suggesting distinct gene-specific responses to the combined effects of supplementation and physical training (52)

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E 2( t ) itself is a piecewise linear function found by applying the spline function in Matlab to the data in Panel A of Figure 2 for estradiol as a function of day of the cycle for the average woman

Bourgi 2026 reported a mean difference in visceral adipose tissue of negative 27.71 cm squared (P less than 0.001) and trunk fat reduction of negative 1.18 kg, with a safety profile judged more favourable than exogenous GH administration