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Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (ChurgStrauss syndrome)

Patient-derived resistant primary cells treated with miR-634 exhibited reduced viability upon treatment with 15 M and 30 M cisplatin, and concurrently enhanced sensitivity to carboplatin and doxorubicin, suggesting that the miR-634 delivery system could serve as a combination therapy strategy to reverse multidrug resistance [61]

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Pregnancy and lactation safety has not been systematically studied, and as with most cosmetic and research compounds lacking definitive pregnancy safety data, conservative practice typically suggests avoiding use during pregnancy unless clearly needed, though the natural occurrence of GHK-Cu in the body and minimal systemic absorption from topical use suggest risk is likely to be low