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[5] In the Alzheimers trial a much larger study MK-677 25 mg produced a 60.1% increase in serum IGF-1 at six weeks and a 72.9% increase at twelve months, which the authors cited as clear evidence of target engagement. [10] The consistency of this IGF-1 rise across independent trials is a key reason MK-677 is treated as a pharmacologically active compound and not a placebo, even though its clinical benefits proved elusive

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